marijuana will increase the amount or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Observe Closely (one)mitotane decreases amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a powerful inducer of cytochrome P-4503A4; keep track of when co